NEUROG3+ endocrine progenitor
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 22 genes have a known function matching the annotation |
Why this annotation
The module is strongly localized to pre_EEC cells, with NEUROG3 (51.6x) and NEUROD2 as hubs, the master regulators of endocrine specification. Non-epithelial genes are restricted to the same subset, so they reflect a transitional state rather than contamination.
Genes
Most correlated modules
- WNT9A/L1TD1 pre-EEC state · correlation 0.89
- HES6 progenitor commitment · correlation 0.87
- SOX4/MEX3A pre-EEC regulators · correlation 0.87
- Progenitor hnRNP program · correlation 0.80
- FGFRL1/VWC2 pre-EEC state · correlation 0.80
- Chaperonin/MYC growth genes · correlation 0.79
- Ribosome/translation machinery · correlation 0.77
- CDKN1C cycle-exit progenitor · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.