PAX4/NKX2-2 specification
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
The endocrine-specification transcription factors PAX4 and NKX2-2 sit alongside the immature-neuronal and progenitor genes TUBA1A, TMSB15B and CD24, peaking in pre_EEC with partial MX_cell signal. It correlates strongly (0.79) with CDKN1C cycle-exit progenitor, consistent with an early specification step.
Genes
Most correlated modules
- Chaperonin/MYC growth genes · correlation 0.88
- HES6 progenitor commitment · correlation 0.79
- CDKN1C cycle-exit progenitor · correlation 0.78
- Progenitor hnRNP program · correlation 0.78
- Biosynthetic housekeeping machinery · correlation 0.73
- Ribosome/translation machinery · correlation 0.72
- SOX4/MEX3A pre-EEC regulators · correlation 0.72
- WNT9A/L1TD1 pre-EEC state · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.