CDKN1C cycle-exit progenitor
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 22 genes have a known function matching the annotation |
Why this annotation
This core-coherence module is strongly localized to pre_EEC cells (with MX_cell signal). It is defined by the p57 cell-cycle inhibitor CDKN1C together with immature neuronal and cytoskeletal genes (TUBB2B, TAGLN3, SEPTIN3) and RASD1/LZTS1, which marks newly committed endocrine precursors exiting the cycle. Its neighbour PAX4/NKX2-2 specification carries the transcription-factor arm of the same step.
Genes
Most correlated modules
- Chaperonin/MYC growth genes · correlation 0.90
- HES6 progenitor commitment · correlation 0.90
- Ribosome/translation machinery · correlation 0.88
- Progenitor hnRNP program · correlation 0.85
- Biosynthetic housekeeping machinery · correlation 0.85
- WNT9A/L1TD1 pre-EEC state · correlation 0.82
- SOX4/MEX3A pre-EEC regulators · correlation 0.79
- PAX4/NKX2-2 specification · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.