SST/HHEX lineage identity
Gene co-expression module in Enteroendocrine cells
| Category | d cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 14 of 17 genes have a known function matching the annotation |
Why this annotation
HHEX, SST, GLP1R, POU3F1 and GAD2 are core members massively enriched in D cells. PDX1, ASCL1 and ST8SIA5 complete the canonical somatostatin D-cell identity and secretory program.
Genes
Most correlated modules
- KATP/hormone-receptor sensing · correlation 0.85
- D/L-cell lineage signature · correlation 0.61
- Peptidergic branch genes · correlation 0.60
- RORB/ECM guidance genes · correlation 0.59
- Beta-cell-like glucose sensing · correlation 0.59
- DAG/PKC signaling · correlation 0.57
- LGR5/NUMBL immature state · correlation 0.53
- Ciliary axoneme genes · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.