RORB/ECM guidance genes
Gene co-expression module in Enteroendocrine cells
| Category | d cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 15 genes have a known function matching the annotation |
Why this annotation
Hubs peak in D cells (CSGALNACT1 39.9x, ADD2 19.3x, COL14A1 15.1x, OLFML3 15.0x) with an echo in MX cells. The module combines RORB, ECM/proteoglycan genes (COL14A1, OLFML3, CSGALNACT1) and semaphorin guidance cues, which distinguishes it from the synaptic-adhesion D-cell module. The fibroblast-typical genes are confined to D cells, so this is genuine rather than contamination.
Genes
Most correlated modules
- Synaptic adhesion genes · correlation 0.83
- KATP/hormone-receptor sensing · correlation 0.79
- L-cell receptor/adhesion program · correlation 0.69
- EC/D presynaptic machinery · correlation 0.68
- Beta-cell-like glucose sensing · correlation 0.67
- DAG/PKC signaling · correlation 0.67
- L-cell Ciliary Genes · correlation 0.65
- Peptidergic branch genes · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.