Synaptic adhesion genes
Gene co-expression module in Enteroendocrine cells
| Category | d cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
Core hubs are sharply restricted to D cells (8–62x) and form a neuronal adhesion, axon-guidance and synaptic-vesicle program (SYT6, CNTNAP5, DSCAM, NEGR1). This likely reflects the neuropod-like paracrine contacts of somatostatin cells.
Genes
Most correlated modules
- RORB/ECM guidance genes · correlation 0.83
- KATP/hormone-receptor sensing · correlation 0.81
- EC/D presynaptic machinery · correlation 0.80
- L-cell Ciliary Genes · correlation 0.72
- DAG/PKC signaling · correlation 0.68
- L-cell receptor/adhesion program · correlation 0.61
- Beta-cell-like glucose sensing · correlation 0.59
- Sensory GPCR/cadherin · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.