CLU/PDZK1 I-cell program
Gene co-expression module in Enteroendocrine cells
| Category | I cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes CLU, PDZK1, CHST9, RHOH, PAG1 and DNM1 are most enriched in I cells, with secondary K/N enrichment, and MGAM2 and PDZK1 mark the small intestine. The module's tight correlation with Small-intestinal Nutrient Sensing (CCK/FFAR1) supports a genuine I-cell accessory identity rather than contamination. Canonical hormone genes are absent, so this is an accessory signature rather than the defining I-cell hormone program.
Genes
Most correlated modules
- Small-intestinal Nutrient Sensing · correlation 0.74
- I-cell identity signature · correlation 0.74
- Small-intestinal absorptive signature · correlation 0.71
- RARRES1/PCSK5 small-bowel program · correlation 0.68
- DAG/PKC signaling · correlation 0.67
- Small-intestinal lipid metabolism · correlation 0.63
- Neurotensin N-cell Program · correlation 0.58
- Beta-cell-like glucose sensing · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.