Beta-cell-like glucose sensing
Gene co-expression module in Enteroendocrine cells
| Category | Glucose homeostasis |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 16 genes have a known function matching the annotation |
Why this annotation
Core hubs GCK, ABCC8 (SUR1), ISL1 and ERO1B form a β-cell-like glucose-sensing secretory program. It is enriched at similar folds across peptidergic subsets, so it is shared rather than subset-specific. The neuronal adhesion and regulatory genes are peripheral.
Genes
Most correlated modules
- KATP/hormone-receptor sensing · correlation 0.77
- LGR5/NUMBL immature state · correlation 0.71
- L-cell AVPR1B/TMEM236 signature · correlation 0.70
- DAG/PKC signaling · correlation 0.70
- L-cell receptor/adhesion program · correlation 0.69
- RORB/ECM guidance genes · correlation 0.67
- FFAR4 lipid sensing · correlation 0.67
- Ciliary axoneme genes · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.