KATP/hormone-receptor sensing
Gene co-expression module in Enteroendocrine cells
| Category | d cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
Hubs are concentrated in D cells at 5–76x. The module carries the SUR2/Kir6.1 KATP pair (ABCC9/KCNJ8), LEPR and SCTR (secretin stimulates somatostatin release), which sets it apart from the D-cell adhesion and ECM modules as a D-cell sensing program. Pericyte-typical genes are restricted to D cells, so this is genuine expression rather than contamination.
Genes
Most correlated modules
- SST/HHEX lineage identity · correlation 0.85
- Synaptic adhesion genes · correlation 0.81
- RORB/ECM guidance genes · correlation 0.79
- Beta-cell-like glucose sensing · correlation 0.77
- DAG/PKC signaling · correlation 0.75
- L-cell receptor/adhesion program · correlation 0.66
- Peptidergic branch genes · correlation 0.64
- EC/D presynaptic machinery · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.