Peptidergic branch genes
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes are modestly enriched across D, INSL5, L, K and MX cells but not EC cells, and the set includes PBX3, the dense-core granule regulator RAB27B and ADCY9 cAMP signalling. This points to a shared peptidergic non-EC branch program. It correlates with the D-cell modules but lacks hormones or lineage TFs, so the label is a best guess.
Genes
Most correlated modules
- L/D-cell excitability genes · correlation 0.72
- L-cell receptor/adhesion program · correlation 0.69
- L-cell Accessory Program · correlation 0.69
- L-cell AVPR1B/TMEM236 signature · correlation 0.68
- FFAR4 lipid sensing · correlation 0.66
- Ciliary axoneme genes · correlation 0.66
- D/L-cell lineage signature · correlation 0.65
- KATP/hormone-receptor sensing · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.