Biosynthetic housekeeping machinery
Gene co-expression module in Enteroendocrine cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 18 of 18 genes have a known function matching the annotation |
Why this annotation
Broadly detected genes for chaperonins (HSPD1/HSPE1/CCT8), proteasome (PSMA7), redox defense (PRDX2/PARK7/TXN), translocon (SEC61B/G) and splicing/transcription (SF3B6/POLR2L) form a generic biosynthetic housekeeping axis. It is only modestly elevated in pre_EEC and MX cells and correlates tightly with the Oxidative Phosphorylation and Abundant housekeeping transcripts modules, which fits a shared cellular-activity program.
Genes
Most correlated modules
- Ribosome/translation machinery · correlation 0.95
- Respiratory chain subunits · correlation 0.94
- Chaperonin/MYC growth genes · correlation 0.91
- Progenitor hnRNP program · correlation 0.90
- Abundant housekeeping transcripts · correlation 0.87
- CDKN1C cycle-exit progenitor · correlation 0.85
- HES6 progenitor commitment · correlation 0.83
- WNT9A/L1TD1 pre-EEC state · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.