Small-intestinal lipid metabolism
Gene co-expression module in Enteroendocrine cells
| Category | Metabolic regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 23 genes have a known function matching the annotation |
Why this annotation
Core hub genes typical of small-intestinal epithelium and lipid handling (CYP4F3, EPHX2, CROT, GK, DPP4, B3GALT5, KIF12) are co-enriched at modest folds across the small-intestine-restricted K, I and N subsets and absent from colonic subsets, so the module reads as a shared small-intestinal metabolic program rather than a subset-specific hormone program. Only GK, CCDC68 and PALS2 are flagged as higher in enterocytes or Paneth cells, so contamination is unlikely to drive the module.
Genes
Most correlated modules
- Small-intestinal absorptive signature · correlation 0.80
- Villus enterocyte-like state · correlation 0.78
- RARRES1/PCSK5 small-bowel program · correlation 0.74
- Peptidergic neuronal-type genes · correlation 0.72
- Peptide tyrosine sulfation · correlation 0.72
- CDX2/HNF4G intestinal identity · correlation 0.71
- Proximal regional identity · correlation 0.69
- Small-intestinal I/K-cell signature · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.