SYT1/ATP6V1C2 vesicle genes
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
All genes are strongly confined to EC cells. The hubs point to dense-core vesicle function: SYT1 as the Ca2+ sensor for exocytosis, ATP6V1C2 for vesicle acidification and SORCS1 for sorting, alongside the secreted neurokine TAFA5. ASPA, B3GNT7 and CGNL1 represent EC expression, not contamination, given their EC localization.
Genes
Most correlated modules
- NAT8L/APOD EC subset · correlation 0.93
- SV2C/KCNS3 EC program · correlation 0.93
- EC accessory genes · correlation 0.93
- FHL1/SCN8A EC state · correlation 0.90
- GREM2/CDH26 EC subset · correlation 0.89
- GULP1/PRDM16 EC genes · correlation 0.87
- Synaptic scaffold/regulators · correlation 0.87
- CDH22/SPATA17 EC markers · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.