TRPM3/KCNIP1 EC signaling
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
This tight EC-localized module combines the TRPM3 cation channel, the Kv4 auxiliary subunit KCNIP1 and the transporters SLC4A8 and SLC16A12 with BMPR1B/PRKD1 signaling. BMP signaling is known to shape EC maturation states. Its strong correlation with the EC accessory genes and the SYT1/ATP6V1C2 vesicle genes confirms an EC-specific program, though the role of most of its genes in EC cells is only partly documented.
Genes
Most correlated modules
- EC Calcium-Triggered Exocytosis · correlation 0.87
- CDH22/SPATA17 EC markers · correlation 0.87
- FHL1/SCN8A EC state · correlation 0.85
- Neuron-like excitability · correlation 0.84
- SYT1/ATP6V1C2 vesicle genes · correlation 0.83
- SYT4+ vesicle state · correlation 0.81
- EC accessory genes · correlation 0.80
- SV2C/KCNS3 EC program · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.