CDH22/SPATA17 EC markers
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
All genes are EC-enriched, led by CDH22 (6.2x) and SPATA17 (4.0x), which are recurrent enterochromaffin markers in gut scRNA-seq, although the serotonin-synthesis genes are absent. Its tight correlation with the FHL1/SCN8A EC state and EC Calcium-Triggered Exocytosis modules places it within the EC program.
Genes
Most correlated modules
- FHL1/SCN8A EC state · correlation 0.93
- EC Calcium-Triggered Exocytosis · correlation 0.89
- Neuron-like excitability · correlation 0.88
- TRPM3/KCNIP1 EC signaling · correlation 0.87
- SYT1/ATP6V1C2 vesicle genes · correlation 0.86
- Synaptic scaffold/regulators · correlation 0.85
- EC accessory genes · correlation 0.85
- Sensory GPCR/cadherin · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.