Neuron-like excitability
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
All genes are EC-enriched, and the hubs are neuronal-type genes: RALYL, MMP16, NRCAM, CNTN4, the dense-core-granule protein PTPRN, the excitability channel KCNH7 and the axonal NMNAT2. Together they define a broadly expressed EC neuron-like excitability program, distinct from the sharply restricted GBX1/PAX9 EC subtype.
Genes
Most correlated modules
- TF-defined EC subtype · correlation 0.88
- CDH22/SPATA17 EC markers · correlation 0.88
- FHL1/SCN8A EC state · correlation 0.87
- EC accessory genes · correlation 0.85
- TRPM3/KCNIP1 EC signaling · correlation 0.84
- EC/D presynaptic machinery · correlation 0.79
- Synaptic scaffold/regulators · correlation 0.79
- SYT4+ vesicle state · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.