Small-intestinal nutrient metabolism
Gene co-expression module in Enteroendocrine cells
| Category | Metabolic regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 14 genes have a known function matching the annotation |
Why this annotation
The module peaks in the small-intestinal K, I and N subsets, with localized PPARα fatty-acid-oxidation targets PDK4 and CPT1A, the aromatic amino-acid transporter SLC16A10 and lipid-handling SEC16B pointing to a nutrient-metabolism state. Top hubs (ETV4, NHSL1, SERPINB1, CDK6) lack metabolic roles, so a broader regional identity program explains the genes about as well.
Genes
Most correlated modules
- CDX2/HNF4G intestinal identity · correlation 0.88
- Small-intestinal I/K-cell signature · correlation 0.82
- Proximal regional identity · correlation 0.81
- RASGRP1/MME K-cell signaling · correlation 0.76
- Villus enterocyte-like state · correlation 0.74
- RARRES1/PCSK5 small-bowel program · correlation 0.72
- Peptide tyrosine sulfation · correlation 0.72
- Proximal MX/I-cell signature · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.