L-cell identity program
Gene co-expression module in Enteroendocrine cells
| Category | l cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Every gene is enriched in L cells with weaker signal in INSL5 cells; hubs SLC4A10, THBS4, FGFBP3 and SYNPR are L-cell-enriched genes in human EEC atlases, and CNR1 regulates GLP-1 secretion. GCG/PYY are absent, lowering certainty slightly.
Genes
Most correlated modules
- L-cell VSTM2A program · correlation 0.88
- ELR+ chemokine secretion · correlation 0.83
- Colonic INSL5+ L-cell · correlation 0.83
- L-cell AVPR1B/TMEM236 signature · correlation 0.76
- GLP-1/PYY hormone program · correlation 0.76
- L-cell Accessory Program · correlation 0.74
- L-cell receptor/adhesion program · correlation 0.72
- SCFA/neuropod sensing · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.