L-cell Accessory Program
Gene co-expression module in Enteroendocrine cells
| Category | l cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Nearly every hub gene (SRGAP3, BCL9, LNX1, NEDD4L, CAPN13, TENT5C, KLF9, AATK) is consistently enriched in L cells at modest folds, and the module tightly co-varies with L-cell receptor/adhesion program. It reads as an L-cell-biased regulatory and signalling state rather than a hormone program.
Genes
Most correlated modules
- L/D-cell excitability genes · correlation 0.85
- D/L-cell lineage signature · correlation 0.79
- Colonic L-cell identity · correlation 0.79
- L-cell VSTM2A program · correlation 0.76
- L-cell receptor/adhesion program · correlation 0.74
- L-cell identity program · correlation 0.74
- Ciliary axoneme genes · correlation 0.72
- Peptidergic branch genes · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.