L-cell receptor/adhesion program
Gene co-expression module in Enteroendocrine cells
| Category | l cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
This core-coherence module peaks in L cells (~6x). AGTR1 (angiotensin II receptor that drives GLP-1 secretion) together with strongly L-enriched PAPPA2, PCDH9, CTNND2 and SLC7A11 define a non-hormone L-cell receptor and adhesion program, with weaker spillover into INSL5 and D cells.
Genes
Most correlated modules
- L/D-cell excitability genes · correlation 0.86
- D/L-cell lineage signature · correlation 0.83
- L-cell Ciliary Genes · correlation 0.81
- FFAR4 lipid sensing · correlation 0.79
- L-cell Accessory Program · correlation 0.74
- L-cell VSTM2A program · correlation 0.74
- L-cell identity program · correlation 0.72
- L-cell AVPR1B/TMEM236 signature · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.