EC/D presynaptic machinery
Gene co-expression module in Enteroendocrine cells
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 22 genes have a known function matching the annotation |
Why this annotation
NALCN subunits UNC79/UNC80, presynaptic organizers NRXN1, ERC2 and PTPRD, endocytic adaptor SNAP91 and scaffold MAGI2 form a neuron-like presynaptic program shared by EC and D cells, consistent with neuropod connections; it is distinguished from «CADM1/ANK2 adhesion axis» by its active-zone/channel composition.
Genes
Most correlated modules
- L-cell Ciliary Genes · correlation 0.84
- Sensory GPCR/cadherin · correlation 0.81
- Synaptic adhesion genes · correlation 0.80
- Neuron-like excitability · correlation 0.79
- CADM1/ANK2 adhesion axis · correlation 0.79
- CDH22/SPATA17 EC markers · correlation 0.72
- ELAVL4 post-transcriptional axis · correlation 0.72
- TRPM3/KCNIP1 EC signaling · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.