L-cell Ciliary Genes
Gene co-expression module in Enteroendocrine cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
A tight module with cilia/axoneme-associated genes (CFAP70, CFAP20DC, ERICH3, WHRN) whose hubs peak in L and INSL5 cells, distinguishing it from the broader peptidergic Ciliary axoneme genes module. Several hubs (SOBP, ELAPOR2, RASSF8, LRMDA) lack a ciliary role and enrichment is modest, so the label is tentative.
Genes
Most correlated modules
- L/D-cell excitability genes · correlation 0.86
- CADM1/ANK2 adhesion axis · correlation 0.84
- EC/D presynaptic machinery · correlation 0.84
- L-cell receptor/adhesion program · correlation 0.81
- D/L-cell lineage signature · correlation 0.80
- ELAVL4 post-transcriptional axis · correlation 0.74
- Synaptic adhesion genes · correlation 0.72
- Sensory GPCR/cadherin · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.