Sensory GPCR/cadherin
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 3 of 8 genes have a known function matching the annotation |
Why this annotation
All genes are EC-enriched (PCDH15 10.1x, ST3GAL1 8.3x), so the DC- and colonocyte-typical flags do not indicate contamination. The mechanosensory cadherin PCDH15, the GPCR GPR158 and the G-protein subunit GNG7 fit EC sensory transduction, and the module correlates tightly with the other EC neuron-like modules. Without serotonin-pathway genes, its specific function stays uncertain.
Genes
Most correlated modules
- CDH22/SPATA17 EC markers · correlation 0.84
- EC/D presynaptic machinery · correlation 0.81
- Neuron-like excitability · correlation 0.78
- L-cell Ciliary Genes · correlation 0.68
- ELAVL4 post-transcriptional axis · correlation 0.62
- CADM1/ANK2 adhesion axis · correlation 0.62
- Minor EC sub-state · correlation 0.58
- Synaptic adhesion genes · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.