ELR+ chemokine secretion
Gene co-expression module in Enteroendocrine cells
| Category | l cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
The hub genes are neutrophil-attracting ELR+ CXC chemokines (CXCL1, CXCL6, CXCL8, PF4V1), plus CD44 and TGFA, and all members are strongly and specifically enriched in L cells. A dissociation artifact would be spread across subsets, so this reads as a genuine inflammatory chemokine-secreting L-cell state.
Genes
Most correlated modules
- L-cell identity program · correlation 0.83
- L-cell VSTM2A program · correlation 0.80
- Crypt-positioned EEC state · correlation 0.77
- Colonic INSL5+ L-cell · correlation 0.75
- GLP-1/PYY hormone program · correlation 0.74
- SCFA/neuropod sensing · correlation 0.65
- L-cell AVPR1B/TMEM236 signature · correlation 0.65
- Colonic L-cell identity · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.