L-cell AVPR1B/TMEM236 signature
Gene co-expression module in Enteroendocrine cells
| Category | l cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Nearly every gene peaks in L cells (TMEM236 4.8x, AVPR1B 4.1x, RAB20 3.5x, MAP2 3.2x) with secondary enrichment in INSL5, N and D cells, pointing to a distal L-lineage signature shared more broadly than the L-cell VSTM2A program; it correlates most tightly with FFAR4 lipid sensing. MRC1 is likely a minor contaminant.
Genes
Most correlated modules
- GLP-1/PYY hormone program · correlation 0.82
- FFAR4 lipid sensing · correlation 0.80
- L-cell identity program · correlation 0.76
- L-cell receptor/adhesion program · correlation 0.71
- Beta-cell-like glucose sensing · correlation 0.70
- L-cell VSTM2A program · correlation 0.68
- Peptidergic branch genes · correlation 0.68
- SCFA/neuropod sensing · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.