Abundant housekeeping transcripts
Gene co-expression module in Enteroendocrine cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 18 genes have a known function matching the annotation |
Why this annotation
The hubs are ubiquitous, highly expressed genes that mix several functions: respiratory chain (COX5A/COX4I1/CYCS), actin (CFL1/ACTG1/MYL12B), ferritin (FTL/FTH1), HSPA8 and HINT1. Together with its tight correlation with the Oxidative Phosphorylation and Biosynthetic Housekeeping Machinery modules, this indicates a shared high-abundance housekeeping axis rather than a subset function.
Genes
Most correlated modules
- Respiratory chain subunits · correlation 0.92
- Biosynthetic housekeeping machinery · correlation 0.87
- Ribosome/translation machinery · correlation 0.76
- Progenitor hnRNP program · correlation 0.72
- Chaperonin/MYC growth genes · correlation 0.65
- CDKN1C cycle-exit progenitor · correlation 0.61
- HES6 progenitor commitment · correlation 0.59
- WNT9A/L1TD1 pre-EEC state · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.