GREM2/CDH26 EC subset
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
Every gene is EC-enriched (GREM2 15.6x, CDH26 8.5x, SPON1 6.5x), and GREM2, SPON1, CDH26, PKDCC and SULF2 are reported EC-enriched genes in EEC atlases. The module lacks TPH1/DDC and LMX1A, so it marks an EC subtype program distinct from «Serotonin biosynthesis» and «LMX1A/VMAT1 EC identity».
Genes
Most correlated modules
- SYT1/ATP6V1C2 vesicle genes · correlation 0.89
- SV2C/KCNS3 EC program · correlation 0.88
- GULP1/PRDM16 EC genes · correlation 0.87
- Synaptic scaffold/regulators · correlation 0.83
- LMX1A/VMAT1 EC identity · correlation 0.80
- EC Calcium-Triggered Exocytosis · correlation 0.80
- FHL1/SCN8A EC state · correlation 0.78
- CDH22/SPATA17 EC markers · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.