FFAR4 lipid sensing
Gene co-expression module in Enteroendocrine cells
| Category | l cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 3 of 12 genes have a known function matching the annotation |
Why this annotation
The top hub is FFAR4 (GPR120), the long-chain fatty-acid receptor that drives GLP-1/PYY release. It is co-enriched with LIPH and RBP4 in INSL5, L and N cells, the distal/ileal L-lineage cells, so the module is a lipid-nutrient-sensing program of these cells. The remaining genes (METRN, CLMP, BAIAP2L1, DOCK4, TSHZ1) are L/N-lineage-associated but have no documented link to lipid sensing.
Genes
Most correlated modules
- L-cell AVPR1B/TMEM236 signature · correlation 0.80
- L-cell receptor/adhesion program · correlation 0.79
- L/D-cell excitability genes · correlation 0.76
- L-cell identity program · correlation 0.69
- Beta-cell-like glucose sensing · correlation 0.67
- Peptidergic branch genes · correlation 0.66
- GLP-1/PYY hormone program · correlation 0.66
- L-cell Ciliary Genes · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.