Cell Cycle Entry
Gene co-expression module in Innate lymphoid cells
| Category | Cell cycle |
|---|---|
| Genes | 7 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 7 genes have a known function matching the annotation |
Why this annotation
Hub genes include EIF1B (eukaryotic translation initiation factor 1B), KMT2E (lysine methyltransferase 2E, H3K4 methylation, chromatin/transcription), TPM4 (tropomyosin 4, actin cytoskeleton), ENY2 (enhancer of yellow 2, transcription/mRNA export), RAB8A (Ras-related GTPase, vesicle trafficking/exocytosis), CCND2 (cyclin D2, cell cycle G1/S transition), LUZP1 (leucine zipper protein 1, cytoskeletal/ciliogenesis). The module is moderate coherence but with many weak membership scores. The genes span cell cycle (CCND2), cytoskeleton (TPM4, LUZP1), vesicle trafficking (RAB8A), chromatin regulation (KMT2E, ENY2), and translation (EIF1B). CCND2 is notable as a marker of NK cell proliferative capacity. The significant delta_inflammation signal and negative delta_treatment response suggest this module is upregulated in inflammation and suppressed by treatment. The combination of CCND2 (cell cycle entry), KMT2E (epigenetic activation), RAB8A (secretory vesicle trafficking), and TPM4 (cytoskeletal remodeling) could reflect NK cell activation/proliferation state. However, the module is mixed. Given CCND2 as a key hub and the cell cycle/activation theme, classifying as cell cycle entry/activation.
Genes
CCND2, EIF1B, ENY2, KMT2E, LUZP1, RAB8A, TPM4
Most correlated modules
- DNA Damage Response · correlation 0.92
- RNA-binding & Splicing · correlation 0.91
- RNA Processing & Proteostasis · correlation 0.90
- Pre-mRNA Splicing · correlation 0.88
- Mitochondrial Housekeeping · correlation 0.87
- Splicing & Transcription · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.