Mitochondrial Housekeeping
Gene co-expression module in Innate lymphoid cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
This module has strong coherence and high mean expression. Hub genes include SUB1 (transcriptional coactivator), EIF1AX (translation initiation), PTMA (prothymosin alpha, chromatin remodeling/cell survival), SKP1 (SCF ubiquitin ligase component), FTH1 (ferritin heavy chain, iron storage/oxidative stress), UBE2D3 (ubiquitin-conjugating enzyme), COX7B and COX7A2 (mitochondrial complex IV subunits), EEF1B2 (translation elongation), SNRPG (spliceosome), POMP (proteasome maturation), SERP1 (ER stress/RAMP4), TMBIM6 (anti-apoptotic ER protein), and ID2 (transcription factor for ILC/NK identity). The module combines mitochondrial OxPhos (COX7B, COX7A2), translation (EIF1AX, EEF1B2), ubiquitin-proteasome (SKP1, UBE2D3, POMP), and RNA processing (HNRNPC, SNRPG) components. The significant delta_inflammation signal suggests this is upregulated in inflamed tissue. The presence of ID2 (a key ILC/NK transcription factor) and the ILC1/res_ILC3 enrichment of some genes suggests this reflects a general housekeeping/metabolic program in active NK/ILC cells. The mix of translation, proteasome, and mitochondrial genes points to a general cellular activity/housekeeping program, but the mitochondrial OxPhos genes are notable. Given the neighbor context (M70 is inflammatory, M60/M20/M61 are housekeeping), this module likely reflects general metabolic activity with a mitochondrial component.
Genes
COX7A2, COX7B, EEF1B2, EIF1AX, FTH1, HNRNPC, ID2, NAP1L1, POMP, PTMA, SERP1, SKP1, SNRPG, SUB1, TMBIM6, TPT1, UBE2D3
Most correlated modules
- ER-Golgi Trafficking · correlation 0.91
- mRNA Stability & Splicing · correlation 0.89
- Innate Stress Signaling · correlation 0.89
- Protein Biogenesis & Import · correlation 0.88
- Cell Cycle Entry · correlation 0.87
- RNA-binding & Splicing · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.