RAB8A — RAB8A, member RAS oncogene family
RAB8A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAB8A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Proteasome Complex Protein processing & ER | HPRT1, MRPL22, MRPS18C, PIN1, PSMB7, PSMD14, PSMD2, PSMD7 +3 more | View in SCUBA |
| CD4⁺ T cells | ER-Golgi Trafficking Protein processing & ER | ALG5, CNIH4, HDDC3, KDELR1, ORMDL2, PYCARD, RASAL3, RBM42 +4 more | View in SCUBA |
| Gamma-delta T cells | Endosomal Vesicle Trafficking Housekeeping | ADRM1, CDK2AP2, CHMP1A, COA6, CYB5B, ELOVL1, GNG5, HADHB +11 more | |
| Innate lymphoid cells | Cell Cycle Entry Cell cycle | CCND2, EIF1B, ENY2, KMT2E, LUZP1, TPM4 | View in SCUBA |
About the gene
| Synonyms | MEL, RAB8 |
|---|---|
| Chromosome | 19: 16111889-16134234 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Autophagy, Cilium biogenesis/degradation, Protein transport, Transport |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Regulates the compacted morphology of the Golgi. Together with MYO5B and RAB11A participates in epithelial cell polarization. Also involved in membrane trafficking to the cilium and ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy. Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10- Rab11-dependent endososomal export route. Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation. Suppresses stress-induced lysosomal enlargement through EHBP1 and EHNP1L1 effector proteins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.