Pre-mRNA Splicing
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include PRPF38B (pre-mRNA processing factor 38B, spliceosome), KTN1 (kinectin, ER-anchored motor receptor), AAK1 (AP2-associated kinase, endocytosis), LARP7 (La-related protein 7, RNA processing/7SK snRNP), HNRNPM (heterogeneous nuclear ribonucleoprotein M, splicing), SSB (La protein, RNA processing), SON (splicing factor), DDX46 (DEAD-box helicase, spliceosome). The module is weak in coherence with many weak membership scores, suggesting a loosely co-regulated set. However, the dominant theme is pre-mRNA splicing and RNA processing (PRPF38B, HNRNPM, SSB, SON, DDX46, LARP7). KTN1, AAK1, LYRM2, KRT10, CIB1, CDC42SE2 are outliers. The significant delta_inflammation signal may reflect increased transcriptional/splicing activity during inflammation. Neighbor context: surrounded by RNA processing modules (M94, M92, M1, M91), strongly supporting this classification.
Genes
AAK1, CDC42SE2, CIB1, DDX46, HNRNPM, KRT10, KTN1, LARP7, LYRM2, PRPF38B, SON, SSB
Most correlated modules
- RNA Processing & Proteostasis · correlation 0.93
- Golgi RNA Processing · correlation 0.92
- Splicing & Transcription · correlation 0.92
- ER-Golgi Trafficking · correlation 0.92
- Endosomal Trafficking · correlation 0.90
- Pyruvate Metabolism · correlation 0.90
- RNA-binding & Splicing · correlation 0.90
- Cell Cycle Entry · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.