DNA Damage Response
Gene co-expression module in Innate lymphoid cells
| Category | Stress |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include HNRNPF (hnRNP RNA binding), MRPS6 (mitoribosomal), TAX1BP1 (NF-κB signaling/autophagy adaptor), XRCC5 (Ku80, DNA double-strand break repair, core membership), CCT6A (chaperonin TRiC subunit, strong membership), ANP32E (chromatin remodeling/histone chaperone), TXN (thioredoxin, redox homeostasis), GNL3 (nucleostemin, ribosome biogenesis). XRCC5 is the core hub gene pointing to DNA repair. TXN adds redox stress. The significant delta_inflammation signal suggests activation-linked upregulation. The combination of DNA repair (XRCC5, TDG), redox (TXN), and chromatin (ANP32E) suggests a DNA damage response/stress program. Neighbor M74 shares chaperone/proteasome themes.
Genes
ANP32E, CCT6A, CLTB, FGFR1OP2, GNL3, HNRNPF, JPT1, MRPS6, PDCD10, RTN4, TAX1BP1, TDG, TRAPPC4, TXN, XRCC5, ZMAT2
Most correlated modules
- RNA Chromatin Regulation · correlation 0.94
- Proteasome ER Proteostasis · correlation 0.94
- Mitochondrial Translation · correlation 0.94
- TRiC Chaperonin Folding · correlation 0.94
- RNA Processing & Proteostasis · correlation 0.92
- Endosomal Trafficking Signaling · correlation 0.92
- Cell Cycle Entry · correlation 0.92
- ER-Golgi Trafficking · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.