RNA-binding & Splicing
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include CALM1 (calmodulin, calcium signaling/cytoskeletal regulation), DYNLL1 (dynein light chain, microtubule motor), NUDC (nuclear distribution protein, involved in dynein-mediated transport and cell division), FUS (RNA-binding protein), HNRNPAB and HNRNPA2B1 (heterogeneous nuclear ribonucleoproteins), NCL (nucleolin, RNA processing), SLC25A3 (mitochondrial phosphate carrier), YWHAQ and YWHAE (14-3-3 proteins, signal transduction scaffolds), SAP18 (splicing/transcription), PPIG (peptidyl-prolyl isomerase G, splicing), SNU13 (snRNP component). The module mixes RNA processing/splicing factors (FUS, HNRNPAB, HNRNPA2B1, SAP18, PPIG, SNU13) with cytoskeletal/transport proteins (DYNLL1, NUDC, CALM1) and 14-3-3 proteins. The moderate coherence and many weak membership scores suggest a mixed module. The dominant theme across hub genes is RNA binding and processing, with a secondary cytoskeletal/transport component. Neighbor context: this batch is dominated by RNA processing modules (M0, M92, M1, M91), supporting an RNA processing classification. The 14-3-3 proteins and DYNLL1 may reflect co-regulation during cell activation or stress. Overall best classified as RNA processing & translation.
Genes
CALM1, DYNLL1, FUS, HNRNPA2B1, HNRNPAB, NCL, NUDC, PPIG, SAP18, SLC25A3, SNU13, YWHAE, YWHAQ
Most correlated modules
- RNA Processing & Proteostasis · correlation 0.93
- Cell Cycle Entry · correlation 0.91
- DNA Damage Response · correlation 0.91
- Splicing & Transcription · correlation 0.90
- Pre-mRNA Splicing · correlation 0.90
- Pyruvate Metabolism · correlation 0.89
- TRiC Chaperonin Folding · correlation 0.89
- Innate Stress Signaling · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.