Translation Initiation
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
The top hub genes by PageRank are EIF3E, EIF3H, and EIF3D — three subunits of the eIF3 translation initiation complex — making translation initiation the dominant program. HNRNPA1 (top PageRank, but weak membership) is an hnRNP involved in mRNA processing and export. SNRPD2 is a core spliceosome component. PSMA2 is a proteasome alpha subunit. ATP5PO and COX4I1/COX7A2L are mitochondrial OxPhos genes (shared with neighbor M42). TMED2 is involved in ER-Golgi trafficking. CDC42 is a Rho GTPase. The module is strongly coherent overall, with eIF3 subunits as the clearest functional anchor. The co-occurrence of OxPhos genes with translation factors likely reflects a shared housekeeping/anabolic program in metabolically active ILC1 cells. The primary identity is translation initiation given the dominance of eIF3 subunits.
Genes
ATP5PO, CCNI, CDC42, CMPK1, COX4I1, COX7A2L, EIF3D, EIF3E, EIF3H, HNRNPA1, PSMA2, SLC25A6, SNRPD2, TMED2, TXNDC12
Most correlated modules
- SUMOylation Program · correlation 0.93
- mRNA Translation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.