SCUBA

SNRPD2 — Small nuclear ribonucleoprotein D2 polypeptide

SNRPD2 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SNRPD2's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsLeukocyte adhesion signaling
migration & adhesion
ARHGDIB, BIN1, CD37, DGKA, DGKZ, EIF3F, EIF3L, EIF4B +22 moreView in SCUBA
CD8⁺ T cellsRNA Splicing & ER
RNA processing & translation
ARHGDIB, FKBP8, HNRNPA1, MIF, PFN1, PPDPF, PPP1R18, TMED2 +2 moreView in SCUBA
EndothelialRespiratory Chain Complex
Mitochondrial & OxPhos
ATP5MG, CHCHD2, HSBP1, MTCH2, NDUFB11, NDUFS8, NDUFV2, UQCR10View in SCUBA
FibroblastsRibosome Biogenesis
Housekeeping
BTF3, EEF1B2, EIF3G, EIF3K, RPL36AL, RPL4, RPS10, SLC25A6 +1 moreView in SCUBA
Gamma-delta T cellsTranslation Initiation
RNA processing & translation
BTF3, C12orf57, COMMD6, COX4I1, COX7C, EEF1B2, EEF1D, EEF1G +18 more
Goblet cellsGlutathione Detoxification
Stress
EIF3K, GSTP1, HINT1, HMGA1, MGST1, MGST3, SLIRP, TST +1 moreView in SCUBA
Innate lymphoid cellsTranslation Initiation
RNA processing & translation
ATP5PO, CCNI, CDC42, CMPK1, COX4I1, COX7A2L, EIF3D, EIF3E +6 moreView in SCUBA
Lymphatic endothelialMitochondrial OxPhos Complex
Mitochondrial & OxPhos
ANAPC11, AP2M1, BRK1, LSM3, MRPL51, MRPS21, NDUFA12, NDUFAB1 +6 moreView in SCUBA
MacrophagesMitochondrial Biogenesis
Mitochondrial & OxPhos
AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 moreView in SCUBA
Mucosal-associated invariant T cellTranslation Elongation
RNA processing & translation
BAX, BTF3, COX4I1, EEF1B2, EEF1D, EIF3K, FAU, FTL +8 more
Smooth muscle cellsRespiratory Chain Subunits
Mitochondrial & OxPhos
C19orf53, COX6A1, COX7B, MZT2B, NDUFB1, PFN1, SNX3, UBXN1 +2 moreView in SCUBA

About the gene

SynonymsSm-D2, SNRPD1
Chromosome19: 45687460-45692569
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Predicted intracellular proteins
Molecular functionRibonucleoprotein
Biological processmRNA processing, mRNA splicing

Function

Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.