SUMOylation Program
Gene co-expression module in Innate lymphoid cells
| Category | Protein processing & ER |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes SUMO2 and SUMO1 (core/strong membership) are the defining SUMOylation components, joined by SUMO3 neighbor context in M78. Supporting genes include PSMA1 (proteasome, protein degradation), HINT1 (nucleotide hydrolase involved in protein quality control), ATP5MG/COX7C (mitochondrial housekeeping), EEF1A1 (translation), YBX1 (RNA binding/stress response), and BTF3 (transcription initiation). The co-occurrence of SUMO1/SUMO2 as strong hub genes alongside proteasome component PSMA1 and the neighbor module M78 containing SUMO3 and PSMC5 points to a SUMOylation and protein quality control program. Strong coherence supports a unified program.
Genes
ATP5MG, ATP6V1G1, BTF3, C4orf3, COX7C, EDF1, EEF1A1, HINT1, OSTC, PSMA1, RACK1, SUMO1, SUMO2, YBX1
Most correlated modules
- Protein Biogenesis & Import · correlation 0.95
- Actin Cytoskeleton Remodeling · correlation 0.94
- Glycolysis & OxPhos · correlation 0.94
- Proteostasis Stress Response · correlation 0.94
- Translation Initiation · correlation 0.93
- ILC-1 identity · correlation 0.93
- RNA Processing & Proteostasis · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.