mRNA Translation
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
Top hub genes EIF3L (eukaryotic initiation factor 3L) and EEF2 (elongation factor 2) are core translation machinery components. PGK1 supports glycolytic energy for translation. HNRNPA0 and HNRNPDL are RNA-binding proteins involved in mRNA processing and stability. CD2BP2 is involved in pre-mRNA splicing. PPDPF is a small protein involved in pancreatic/cellular stress. The module reflects active mRNA processing and translation, consistent with ILC1 housekeeping. MAP2K1 and ZBTB16 are peripheral members that weaken the signal.
Genes
ABHD14B, ARHGDIA, CD2BP2, EEF2, EIF3L, GYPC, H2AJ, HNRNPA0, HNRNPDL, LAPTM5, MAP2K1, PGK1, PPDPF, PRNP, ZBTB16
Most correlated modules
- Translation Initiation · correlation 0.88
- IFN-driven ILC1 Activation · correlation 0.82
- Mitochondrial Organization · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.