CDC42 — Cell division cycle 42
CDC42 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDC42's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Translation Initiation RNA processing & translation | ATP5PO, CCNI, CMPK1, COX4I1, COX7A2L, EIF3D, EIF3E, EIF3H +6 more | View in SCUBA |
| Lymphatic endothelial | Protein Quality Control Protein processing & ER | BCAP29, CD99, DYNLRB1, GNG5, NDUFV2, PDCD6, PFDN5, SKP1 +1 more | View in SCUBA |
| Macrophages | Actin Cytoskeleton Organization Cytoskeletal | ACTR3, ARF1, ARHGDIA, ARPC4, DERL1, EIF4G2, GARS1, HNRNPK +20 more | View in SCUBA |
| Smooth muscle cells | Rho GTPase Housekeeping Housekeeping | CST3, DDT, OST4, POLR2L, PRELID1, RHOC, SCAND1 | View in SCUBA |
About the gene
| Synonyms | CDC42Hs, G25K |
|---|---|
| Chromosome | 1: 22052627-22101360 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Hydrolase |
| Biological process | Differentiation, Neurogenesis |
Function
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. Upon activation by PLEKHG4B, involved in actin cytoskeletal remodeling during epithelial cell-cell junction formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.