EIF3D — Eukaryotic translation initiation factor 3 subunit D
EIF3D belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EIF3D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Translation machinery Housekeeping | ATP5PO, BTF3, COX4I1, EEF2, EIF3G, EIF3K, MZT2B, RACK1 +2 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ANKRD13D, ATP5ME, ATP5MJ, CAMTA1, CD2, CTDNEP1, DPP7, FBL +11 more | |
| Goblet cells | mRNA Translation Initiation RNA processing & translation | EEF1A1, EEF1B2, EIF3E, EIF3F, EIF3L, PABPC1, RACK1, SLC25A6 +2 more | View in SCUBA |
| Innate lymphoid cells | Translation Initiation RNA processing & translation | ATP5PO, CCNI, CDC42, CMPK1, COX4I1, COX7A2L, EIF3E, EIF3H +6 more | View in SCUBA |
| Macrophages | Translation Initiation Housekeeping | AKR1B1, CAMLG, CAPZB, EEF1D, EEF2, EID1, EIF3E, EIF3F +26 more | View in SCUBA |
About the gene
| Synonyms | eIF3-p66, eIF3-zeta, EIF3S7 |
|---|---|
| Chromosome | 22: 36510855-36529184 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Initiation factor, RNA-binding |
| Biological process | Host-virus interaction, Protein biosynthesis |
Function
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.