COX7A2L — Cytochrome c oxidase subunit 7A2 like
COX7A2L belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COX7A2L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Translation Mitochondrial & OxPhos | ABRACL, DNAJC7, EGLN2, FAM217B, IL10RB, MPLKIP, MRPL36, MRPS10 +11 more | |
| Goblet cells | Epithelial Maintenance Housekeeping | DDAH2, IP6K2, LAPTM4A, MARCKS, METTL9, MKRN1, RNF44 | View in SCUBA |
| Innate lymphoid cells | Translation Initiation RNA processing & translation | ATP5PO, CCNI, CDC42, CMPK1, COX4I1, EIF3D, EIF3E, EIF3H +6 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ATP6V1D, ATP6V1E1, BAX, C1orf43, DCUN1D5, DNAJC15, DNAJC8, ENY2 +28 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial OxPhos Mitochondrial & OxPhos | ATP5PD, CD63, CDK2AP2, MDH1, MESD, MRPS18C, MRPS31, NDUFS2 +5 more | |
| Smooth muscle cells | Mitochondrial Housekeeping Housekeeping | APP, EIF5B, GABARAPL2, LAMTOR4, NDUFAB1, PGAM1, SPCS2, TMEM14C +2 more | View in SCUBA |
About the gene
| Synonyms | COX7AR, COX7RP, EB1, SCAF1, SCAFI, SIG81 |
|---|---|
| Chromosome | 2: 42333546-42425088 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
Assembly factor that mediates the formation of some mitochondrial respiratory supercomplexes (respirasomes), thereby promoting oxidative phosphorylation and energy metabolism. Acts as a molecular adapter that associates with both mitochondrial respiratory complexes III (CIII) and IV (CIV), promoting their association. Mediates the formation of various mitochondrial respiratory supercomplexes, such as MCIII(2)IV(2), composed of two CIII and two CIV, and the CS-respirasome (MCI(1)III(2)IV(2)), composed of one CI, two CIII and two CIV. Not involved in the formation of the canonical respirasome (MCI(1)III(2)IV(1)), composed of one CI, two CIII and one CIV (By similarity). The formation of different respirasomes is important for cell adaptation to oxygen conditions and prevent metabolic exhaustion: supercomplexes mediated by COX7A2L/SCAF1 are required to maintain oxidative phosphorylation upon low oxygen conditions and promote metabolic rewiring toward glycolysis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.