Hippo-mTOR Quiescence
Gene co-expression module in Lymphatic endothelial
| Category | endothelial development |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include FRMD6 (Hippo pathway, contact inhibition/quiescence), PRR5L (mTORC2 signaling), BCAT1 (branched-chain amino acid metabolism), LAMA4 (basement membrane laminin), and FILIP1 (cytoskeletal/filamin interaction). Together these suggest a quiescent lymphatic endothelial state with Hippo-mediated growth suppression, ECM anchoring, and metabolic homeostasis. NIBAN1 adds a stress-protective component. This combination is consistent with a homeostatic/quiescent lymphatic program rather than active remodeling or inflammation.
Genes
BCAT1, FILIP1, FRMD6, KLHL3, LAMA4, NIBAN1, PRR5L, SCN9A
Most correlated modules
- Lymphatic EC Identity · correlation 0.85
- Lymphatic Valve Development · correlation 0.79
- Lymphangiogenesis ECM · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.