Lymphatic EC Identity
Gene co-expression module in Lymphatic endothelial
| Category | Gut residence |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include IL7 (canonical lymphatic EC marker), CD36 (fatty acid/lipid uptake), CHST15 (glycosaminoglycan sulfation), CERS6 (ceramide synthesis), EPS15 and ITSN1 (endocytosis), THSD7A (endothelial thrombospondin domain), DOCK5 (Rho GEF), and FRMD4B (cell polarity). IL7 is a defining marker of intestinal lymphatic ECs. CD36 and CERS6 link to lipid handling, consistent with lacteals. The combination of lymphatic identity marker (IL7), lipid metabolism (CD36, CERS6), and endocytic machinery (EPS15, ITSN1) defines a lymphatic EC identity program with lipid uptake function.
Genes
CD36, CERS6, CHST15, DOCK5, EPS15, FRMD4B, FRY, IL7, ITSN1, KIAA1217, KIAA1671, LIMCH1, THSD7A
Most correlated modules
- Lipid Metabolic Regulation · correlation 0.97
- Chromatin Remodeling · correlation 0.94
- Lymphatic Valve Development · correlation 0.94
- Hypoxia Response · correlation 0.93
- Cilia Centrosome Program · correlation 0.92
- Polarized Vesicle Trafficking · correlation 0.91
- Focal Adhesion Migration · correlation 0.90
- Endosomal Vesicle Trafficking · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.