SCN9A — Sodium voltage-gated channel alpha subunit 9
SCN9A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SCN9A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Retinoid Stromal Quiescence Developmental | ACAN, GALNT17, KCTD8, NDUFA4L2, NTRK3, PCDH17, PDE8B, RBP4 +5 more | View in SCUBA |
| Glial cells | Glial RNA Homeostasis RNA processing & translation | ATRX, DYNC1H1, GTF2I, NCL, RBM25, SRSF11, SYNM | View in SCUBA |
| Lymphatic endothelial | Hippo-mTOR Quiescence endothelial development | BCAT1, FILIP1, FRMD6, KLHL3, LAMA4, NIBAN1, PRR5L | View in SCUBA |
About the gene
| Synonyms | ETHA, Nav1.7, NE-NA, NENA, PN1 |
|---|---|
| Chromosome | 2: 166195185-166376001 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Ion channel, Sodium channel, Voltage-gated channel |
| Biological process | Ion transport, Sodium transport, Transport |
Function
Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage- gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.