PRR5L — Proline rich 5 like
PRR5L belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRR5L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAP1, ALOX5AP, AOAH, CD244, CMIP, CPNE7, CRTAM, DAPK2 +15 more | View in SCUBA |
| Enterocytes | SATB2 colonic identity Epithelial development | C1orf21, FOXP2, PALS2, PDE3A, PRKG1, RNF152, SATB2 | View in SCUBA |
| Gamma-delta T cells | NK-like Terminal Differentiation T cell maturation | EPB41L4A, FCRL6, JAZF1, LILRB1, MLC1, SYT11, ZEB2 | |
| Lymphatic endothelial | Hippo-mTOR Quiescence endothelial development | BCAT1, FILIP1, FRMD6, KLHL3, LAMA4, NIBAN1, SCN9A | View in SCUBA |
| Natural Killer cells | Innate Sensing NK Regulation Immune regulation | ADRB2, DTHD1, FCRL6, LFNG, LIMD2, PLEK, PYHIN1, UBE2F +1 more | View in SCUBA |
About the gene
| Synonyms | FLJ14213, PROTOR-2 |
|---|---|
| Chromosome | 11: 36296288-36465204 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Signal transduction inhibitor |
Function
Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration. Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM- CSF, in response to stress. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.