Lymphatic Valve Development
Gene co-expression module in Lymphatic endothelial
| Category | Valve formation |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include NFIA and NFIB (Nuclear Factor I transcription factors, critical regulators of lymphatic EC specification and valve formation), MEF2C (MEF2 transcription factor, essential for lymphatic valve development), RECK (MMP inhibitor, ECM remodeling), SEMA6A (semaphorin, vascular/lymphatic guidance), PXN (paxillin, focal adhesion/migration), UTRN (utrophin, cytoskeletal), LRP5 (Wnt signaling co-receptor, lymphatic development), SH2D3C (signaling adaptor). NFIA, NFIB, and MEF2C are all documented regulators of lymphatic valve formation and lymphatic EC identity. This module strongly represents lymphatic valve development transcriptional program.
Genes
GPM6A, LRP5, MEF2C, MPP7, NFIA, NFIB, PGM5, PRKAR1B, PXN, RECK, SEMA6A, SH2D3C, STON2, UTRN
Most correlated modules
- Lymphatic EC Identity · correlation 0.94
- Actin Cytoskeletal Scaffold · correlation 0.94
- Hypoxia Response · correlation 0.93
- Lipid Metabolic Regulation · correlation 0.93
- Chromatin Remodeling · correlation 0.92
- Endosomal Vesicle Trafficking · correlation 0.90
- Lymphangiogenesis ECM · correlation 0.90
- Endothelial Receptor Signaling · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.