Type I Interferon
Gene co-expression module in Lymphatic endothelial
| Category | Inflammation |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
The module is dominated by canonical interferon-stimulated genes: IFIT1, IFIT2, IFIT3, IFI6, ISG15, OAS1, MX1, BST2 — all well-established type I IFN response genes. CD74, HLA-DRA, and HLA-DRB1 reflect MHC class II upregulation, which co-occurs with IFN-gamma signaling. CLEC14A is a lymphatic/endothelial marker providing cell-type context. RBP1 is a peripheral member. This is a coherent interferon response module in lymphatic endothelial cells, consistent with the positive delta_inflammation_CD trend.
Genes
BST2, CD74, CLEC14A, HLA-DRA, HLA-DRB1, IFI6, IFIT1, IFIT2, IFIT3, ISG15, MX1, OAS1, RBP1
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.