MX1 — MX dynamin like GTPase 1

MX1 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MX1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Type I Interferon Anti-viral	GBP2, GBP4, IRF9, ISG15, ISG20, LY6E, MNDA, MX2 +9 more	View in SCUBA
CD4⁺ T cells	Interferon response Anti-viral	ACBD5, AQP3, BTN2A1, BTN3A2, BTN3A3, CISH, EIF2AK2, ERAP2 +23 more	View in SCUBA
CD8⁺ T cells	Type I Interferon Inflammation	EPSTI1, IFI35, IFI44, IFI44L, IFI6, IRF7, ISG15, LGALS9 +3 more	View in SCUBA
Endothelial	Type I Interferon Inflammation	CMPK2, HELZ2, IFI44, IFI44L, IFI6, IFIT1, IFIT2, IFIT3 +9 more	View in SCUBA
Fibroblasts	Type I Interferon Inflammatory	APOL6, BATF2, CXCL10, GBP1, IFI44L, IFIT2, IFIT3, ISG15 +6 more	View in SCUBA
Gamma-delta T cells	TCR Signal Regulation TCR Signaling	ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CDC14A, CXCR6 +22 more
Lymphatic endothelial	Type I Interferon Inflammation	BST2, CD74, CLEC14A, HLA-DRA, HLA-DRB1, IFI6, IFIT1, IFIT2 +4 more	View in SCUBA
Macrophages	Type I Interferon Antiviral	CCL8, CMPK2, HELZ2, IFI27, IFI44, IFI44L, IFI6, IFIT1 +13 more	View in SCUBA
Monocytes	Type I Interferon Response Antiviral	EPSTI1, IFI44, IFI44L, IFI6, IRF7, OAS2, OAS3, PARP12 +1 more	View in SCUBA
Mucosal-associated invariant T cell	Type I Interferon Inflammation	DDX60, DDX60L, DTX3L, EIF2AK2, EPSTI1, GBP2, GBP4, HERC5 +18 more
Pericytes	Type I Interferon Inflammatory	IFI16, IFI44L, IFI6, PPIC, RCN1, SP100, TNFRSF1A, XAF1	View in SCUBA

About the gene

Synonyms	IFI-78K, lncMX1-215, MxA
Chromosome	21: 41420020-41470071
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Biological process	Antiviral defense, Immunity, Innate immunity

Function

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress- mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.