NK-like Cytotoxic
Gene co-expression module in Mucosal-associated invariant T cell
| Category | cytotoxicity |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
FCGR3A (CD16), CX3CR1, KIR3DL1, GNLY, FGFBP2, and CLIC3 are hallmarks of terminally differentiated NK cells or NK-like cytotoxic T cells. CX3CR1 and KIR3DL1 in particular mark NK/NKT terminal effectors. PTGDS, PRSS23, and AKR1C3 are also enriched in NK-like effectors. This module likely represents NK-like terminally differentiated MAIT cells or NK cell contamination, neighboring the myeloid contamination module (M37) and cytotoxic programs.
Genes
AKR1C3, BNC2, CLIC3, CX3CR1, FCGR3A, FGFBP2, GNLY, IGFBP7, KIR3DL1, LINGO2, PRSS23, PTGDS
Most correlated modules
- Naive T cell · correlation 0.76
- Chromatin Remodeling · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.