GNLY — Granulysin
GNLY belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNLY's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADGRG1, ATP8B4, CCL3, CCL4, CCL4L2, CSF2, FASLG, GZMB +10 more | View in SCUBA |
| CD8⁺ T cells | Cytotoxic Gut Effector cytotoxicity | ATP8B4, CCND2, CD63, CEBPB, CSF1, CTSA, GNPTAB, GZMA +3 more | View in SCUBA |
| Gamma-delta T cells | Cytotoxic Effector Program cytotoxicity | ADGRG1, ANXA4, CADM1, CX3CR1, FCGR3A, FGFBP2, FGL2, GZMB +14 more | |
| Innate lymphoid cells | NK Homing Circulating Homing & TEM | ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 more | View in SCUBA |
| Mucosal-associated invariant T cell | NK-like Cytotoxic cytotoxicity | AKR1C3, BNC2, CLIC3, CX3CR1, FCGR3A, FGFBP2, IGFBP7, KIR3DL1 +3 more | |
| Natural Killer cells | Granulysin Cytotoxic Effector Cytotoxicity | ARL4C, DSTN, EMP3, FLNA, S100A4, S100A6, TIMP1, VCL | View in SCUBA |
About the gene
| Synonyms | D2S69E, LAG-2, LAG2, NKG5, TLA519 |
|---|---|
| Chromosome | 2: 85685175-85698852 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins, Transporters |
| Molecular function | Antibiotic, Antimicrobial, Fungicide |
Function
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.